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MAbs 5 , 962973 (2013)

Both 18 six-month-old male Nrf2 KO mice and 18 wild-type (WT) mice with a C57BL/6 background were housed under specific pathogen free (SPF) conditions with a 12:12-hour light-dark cycle and had free access to food and water

Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature

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1 for mild signs (slight facial swelling)