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Glutamate and -KG serve as important exchangers in the MAS, and since GLS1 knockdown significantly suppresses NADH and ATP production in cancer cells 143 , the supply of glutamate and -KG for the induction of MAS activity is evidently critical for ATP production in cancer cells (Fig

The reaction mixture was incubated in boiling water for 20 min and cooled to room temperature

The outcome could shape future drug marketing , FDA warning requirements , and patient safety protections for years to come.

It includes conditions such as early-onset encephalopathy with progressive muscle weakness, failure to grow, low blood sugar [84], ketoacidosis, and encephalopathy

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