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Smoking decreases the effectiveness of glutathione, making it harder for your body to combat oxidative stress

It is primarily used to treat vitamin B12 deficiency, which can lead to anemia, fatigue, and neurological symptoms

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Hazel Szeto and Peter Schiller at Cornell University

Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS