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This peptide has been implicated in modulating neuronal cell differentiation, neurite outgrowth, and performing neuroprotective functions through the activation of GLP-1 receptors (GLP-1Rs), class B sub-group G protein-coupled receptors [2, 6]

Landmark Clinical Evidence: LEADER, SUSTAIN-6, and REWIND The decisive shift from glucose-centric therapy to cardiorenal risk modification began with three large cardiovascular outcome trials (CVOTs) evaluating long-acting GLP-1 receptor agonists (Table 1, Table 2)

doi:10.3109/09513590.2015.1080680

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