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Its origin is multifactorial and appears related to immature liver enzyme systems (such as glucuronyl transferase ), a higher turnover of red cells (incorporating the transition from fetal to adult haemoglobin) and, occasionally, to the effects of breastfeeding

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Finally, the clinical studies summarized used collagen (bovine or animal sources such as fish, collagen peptides, and hydrolyzed collagen, where some test materials were commercially available products while others used multiple custom formulations), which are noted in the brief descriptions above