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[1] [2] The vitamin's water-soluble nature means that excess amounts are typically excreted through urine rather than accumulating in the body to toxic levels

Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

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These cells are primarily known for their ability to target and destroy infected viral or tumor cells, but they also produce cytokines that can modulate the immune response