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Modulation of nitric oxide synthase (NOS) isoforms by 1,25(OH) 2 D 3 observed in our study aligns with previous findings suggesting that vitamin D plays a significant role in regulating vascular homeostasis and reducing oxidative stress [14, 66, 67]

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Moreover, inflamed tissues have more activated macrophages or other monocytes and changes in pH that can be utilized as targets for site-specific drug delivery systems as nano-carriers [19, 20]

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