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For the NsPCSs immobilized on the cellulose sponge, the -EC yield was reduced with repeated reactions: In the fifth reaction, the yield after 48 h was reduced to 26% of the first reaction (Fig

This orphan status has created a dichotomy in the scientific community: while empirical evidence from animal models and human clinical trials in the 1980s demonstrated significant therapeutic potential, particularly in addiction and stress management, the lack of a defined molecular pathway has stalled its development into a licensed pharmaceutical agent

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