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Tolerability: Adverse events mainly include mild nasal irritation in 10%-15% of subjects (example: transient congestion or mild discomfort), with no serious adverse events documented by trial sponsors and researchers

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Michels KB, Willett WC, Fuchs CS, Giovannucci E (2005)

On one hand, activity at such vanishingly small concentrations is consistent with GHK-Cus proposed role as a physiological signaling molecule rather than a blunt pharmacological agent, which is genuinely intriguing