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From SURPASS-2 (tirzepatide for diabetes, N=1,879): The orthostatic hypotension signal is relevant because dehydration reduces blood volume, which causes blood pressure to drop when standing

It might look impressive in the short term, but when the tide comes in, everything washes away

Hadar A, Kapitansky O, Ganaiem M, Sragovich S, Lobyntseva A, Giladi E, et al

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First and foremost is the threat to research integrity