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NAC and GSH exhibited pro-oncogenetic effects on human HCC cells and desensitized NRF2/GCLC related antioxidant production pathway in vitro Since we observed that antioxidants promoted tumorigenesis and growth in mouse spontaneous HCC and xenograft models, we wished to confirm whether these promoting effects also existed in human HCC cells both in vitro and in vivo

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Acknowledgements The authors wish to thank Mr Maxime Francois for his translation of Golse et al

Specifically, MSC- Igf1r / mice had less trabecular bone as defined by a significant decrease in the percent of bone volume per tissue volume (BV/TV) ( P =0.01) and trabecular thickness (Tb.Th) ( P =0.002) relative to their wt littermates (Figure 4B)

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