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68,69 In addition to activating the cAMP/PKA pathway, activation of GLP-1R has been associated with other intracellular mechanisms such as the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which plays a crucial role in regulating key functions like cell survival, mitochondrial activity, and autophagy, or the breakdown and recycling of damaged cellular components

Aertgeerts K, Levin I, Shi L, Snell GP, Jennings A, Prasad GS, et al

The number of studies included in the present study was too low to conclusively assess heterogeneity

I actually may ask them to track their diet, maybe put a wearable on or looking at steps, maybe looking at their sleep if they're digitally minded