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Metformin is either weight neutral or induces moderate weight loss, and it reduces mortality and cardiovascular events in patients with type 2 diabetes

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Jardiance can cause mild weight loss, but it is usually less significant than with Ozempic

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In M1 macrophages, a low ratio of -KG as a result of glutamine producing succinate can enhance their proinflammatory phenotype, which is beneficial for inhibiting the growth of tumor cells and enhancing their own immune function [24, 28] (Fig