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Semaglutide GLP-1 works by affecting the hypothalamus area of the brain, which is the region tasked with controlling hunger and fullness cues

In pharmacodynamic studies, tirzepatide demonstrated dose-dependent slowing of gastric emptying, with the effect being most pronounced during the early treatment period and showing some attenuation over time with continued use

In Re: Glucagon-like Peptide-1 Receptor Agonists (GLP-1 RAs) Non-Arteritic Anterior Ischemic Optic Neuropathy Products Liability Litigation , MDL 3163, currently has 29 pending cases