Start conservatively with 100-150mg daily - Begin with smaller doses for 2 weeks, then progress to 250-500mg split into two daily doses for optimal tolerance and results
No change in cortical ADC was observed in the combination-therapy group compared with baseline or placebo (0.0510 3 mm 2 /s [95% CI 0.15, 0.05], p =0.29 when compared with placebo, corresponding to a reduction of 1%)
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Higher levels of diet ME increased broiler performance, though no significant interactions could be found between energy and carnitine levels
Since dyslipidemia and microalbuminuria are reversible in type 2 diabetic patients, it is possible that high dose thiamine therapy might improve renal function and metabolic control through reduction in biochemical dysfunction and improvement in thiamine dependant enzyme activities in diabetic patients with existing dyslipidaemia and microalbuminuria
