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Although thymosin beta4 is considered non-toxic, its involvement in angiogenesis and cell proliferation necessitates further investigation for long-term human safety. Xu et al., Peptides Sourcing and Purity Due to its legal gray area, most TB500 available for purchase is sold as a research chemical and not regulated for pharmaceutical quality

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doi:10.1007/BF02284971

Short peptides offer manageable models for studying larger protein interactions