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Its becoming a multi-disease cardiometabolic platform spanning: Cardiovascular disease Obstructive sleep apnoea (OSA) MASH Chronic kidney disease And importantly: Oral obesity therapy is now real not theoretical But the category is already splitting: Peptide oral (with friction) Small-molecule oral (lower friction) That distinction will matter more than pill vs injection Peptide oral (with friction) Small-molecule oral (lower friction) That distinction will matter more than pill vs injection The Most Misunderstood Opportunity: OSA OSA has gone from interesting to commercially meaningful fast Tirzepatide is now the first approved drug for OSA in obesity Phase 3 data showed:~2529 events/hour reduction in AHI Up to ~50% reaching disease-resolution criteria Thats real

Anyone telling you otherwise cares more about your money than your well-being

Prediabetes alone usually doesnt qualify, though this can vary by state

Collectively, these data indicate that GLP-1 is non-redundantly regulated in both lean and obese Tmprss2 / mice, which is in contrast to the primary effect of GIP suppression observed in PAR2-G37I mice

No significant differences were shown for fatty liver index (FLI) or hepatic steatosis index (HIS) in either group at 24 weeks of therapy