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The clinical application of GIP agonists for the treatment of diabetes is hampered by this increase in glucagon secretion, which has also been verified in both healthy and subjects with T2DM [19, 20]

According to FDA prescribing information, approximately 6% of patients receiving Zepbound discontinued treatment due to adverse reactions compared to 2-3% receiving placebo, with gastrointestinal events being the most common reasons for discontinuation

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Effects of glucagon-like peptide-1 receptor agonists on gut microbiota in dehydroepiandrosterone-induced polycystic ovary syndrome mice: Compared evaluation of liraglutide and semaglutide intervention

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