A possible explanation is that DPP-IV inhibition could not raise the GLP-1 levels sufficiently to therapeutic range when the basal GLP-1 level was too low to begin with ( The differences in the magnitude of treatment responses to linagliptin between the high and low GLP-1 levels was more pronounced in T2D than prediabetes
Some of the side effects we found, like nausea, are well known, and that shows that the method is picking up a real signal, says Sharath Chandra Guntuku, Research Associate Professor in Computer and Information Science (CIS) at Penn Engineering and the studys senior author
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Although SGLT-2 inhibitors and GLP-1 receptor agonists do not increase the risk of severe hypoglycemia, SGLT-2 inhibitors increase the risk of genital infections, and GLP-1 agonists have gastrointestinal adverse effects, especially at initiation and with high doses
