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Specifically, blocking the 1-adrenergic receptors with prazosin or the opioid receptors with nalbuphine interfered with the ability of GLP-1RAs to reduce plasma TNF- levels, indicating the critical importance of these pathways in the anti-inflammatory effects mediated by GLP-1 activation

While increasing dietary fiber through vegetables, fruits, and whole grains helps promote regularity (aiming for 25-30g daily per US Dietary Guidelines), patients should maintain adequate hydration to support both protein metabolism and bowel function

This helps ensure that the medication is safe and effective for use

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Napoli R, Berra C, Catarig AM, et al