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Thats because of the big first difference well mention: metformin isnt a GLP-1 agonist

Ozempic (semaglutide) is a prescription medication that is approved only in injectable form

10.1007/s12272-025-01574 84 LuX.XuC.DongJ.ZuoS.ZhangH.JiangC.et al (2021)

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Alertness, focus perceiving and mood perceiving were measured insignificantly in one study (19)