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Side Effects: What You're Likely to Experience If youve tried or have known about the side effects of Mounjaro injection, youll feel familiar with these as well: Nausea (usually improves after the first few weeks) Constipation Diarrhoea or loose stools Reflux or heartburn Reduced appetite (actually an effect more than a side effect) The good news: Based on clinical data, GI related side effects in men tend to be slightly less severe than in women on average