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Metabolomic pathway analysis of the tumours showed that Retatrutide downregulated metabolic pathways key to energy production and cell growth, such as oxidative phosphorylation and glycolysis, supporting the hypothesis that GLP-1R agonist-induced fasting could reduce cancer growth

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When bone tissue is broken down by osteoclasts (the cells responsible for resorption), collagen fibers are degraded and deoxypyridinoline is released into circulation

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