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Recently, the GIP/GLP-1R co-agonist tirzepatide has gone through several randomized controlled trials and was approved by the FDA for T2DM and obesity in 2022 and 2023, respectively

In contrast, participants receiving a placebo lost only about 2.1% of their body weight

While GLP-1 has been used successfully in treating diabetes and aiding in weight loss, GIP's potential is still being explored, particularly when used together with GLP-1

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If a person is not consuming enough protein to replenish their amino acids which many who are on these weight loss drugs arent the body will start recycling muscle to make up for it