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However, these are all speculative applications without any human trial evidence as of 2026

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MASLD is estimated to affect over 30% of the worldwide population, with prevalence rates exceeding 70% in individuals with T2DM, underscoring the severity of this metabolic-hepatic nexus (Garg and Zein, 2025)

Furthermore, NAC directly evidenced antidepressant-like effects in rodent models of depression through its role as an antioxidant (45, 46)