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In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.2-, 0.5-, and 3-fold the exposure at the MRHD)

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Semaglutide reduced ELF score and VCTE-measured liver stiffness, and improved N-terminal type III collagen propeptide (PRO-C3) and the FibroScan-AST (FAST) score, markers associated with fibrotic activity and risk stratification in MASLD [7,13,14]