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Differences in receptor binding and pharmacodynamics could explain this observation, but further investigation is needed to determine whether the differences stem from drug properties, population characteristics or both. The authors also disclosed their inability to establish causality for the association between semaglutide and ocular AEs, noting that the biological mechanisms remain unclear

Biol Psychiatry 57 : 549558

However, cyclosporine, a p-glycoprotein inhibitor, did not reduce the renal clearance of sitagliptin.

The amounts of protein, as a % of the calories consumed, is a major variable in the population

PMID 35514542