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Application of polyphenolic compounds in animal nutrition and their promising effects

In a comprehensive meta-analysis including 76 RCT and more than 39 thousand participants with type 2 diabetes, treatment with GLP1RAs was associated with a reduction in HbA1c of -0.6% to -2.1% as well as reduction of -10.8 to -57.7 mg/dl in the fasting blood glucose levels relative to placebo [14]

La efectividad de estos compuestos en reduccin de HbA1c es dosis dependiente (Tabla 8), su uso no se asocia a hipoglicemia y, en forma adicional, producen baja de peso, disminucin de la PA y un modesto aumento de 5% de colesterol HDL, condiciones consideradas un factor agregado favorable para pacientes con sobrepeso e HTA

This is particularly evident in specific cardiovascular conditions such as heart failure with preserved ejection fraction (HFpEF), for which effective treatments are scarce

According to the American Association of Clinical Endocrinologists the and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications must not be used during pregnancy