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That said, their simultaneous use should be approached with caution

These medications also increase potassium levels, and combining them with spironolactone can result in harmful interactions

For patients with established cardiovascular disease or increased risk factors, both medications offer meaningful protection against serious cardiovascular events including heart attack and cardiovascular death

In clinical trials, GI side effects occur in roughly 4050% of patients on either medication, though they are typically mild to moderate and tend to improve over the first 812 weeks

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