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As demonstrated by Driscoll et al., the precise geometry of the catcher-based bispecific antibodies can have a profound impact on the functionality of the reagents 34

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reported greater weight loss in obese mice with the GLP-1/GIP/glucagon receptor triagonist compared to GLP-1 receptor agonists, GIP/GLP-1 receptor co-agonists and GLP-1/glucagon receptor agonists including semaglutide and tirzepatide [60]

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