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However, due to insufficient understanding of their pathogenesis, late-stage diagnosis, and rapid progression, clinical management strategies for liver disease still face significant challenges, directly contributing to suboptimal therapeutic outcomes [2]

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Laurdan is a non-species-specific lipid probe that cannot discriminate between different lipids at the plasma membrane so that its lateral diffusion would represent the movement of other lipids besides cholesterol, hence potentially explaining the lack of effect on its lateral diffusion by expression of the mutant versus WT receptors

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(PubMed) US Department of Health & Human Services, National Heart Lung and Blood Institute