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DSIP (delta sleep-inducing peptide) was first isolated from rabbit cerebral venous blood in 1974 and has accumulated a small but published clinical-trial base most notably a 1992 Schneider-Helmert study showing improved sleep with DSIP infusion in chronic insomniacs over 7 successive nights and earlier studies showing improved sleep duration in middle-aged chronic insomniacs

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(2020) The effects of N-acetylcysteine on inflammatory and oxidative stress biomarkers: A systematic review and meta-analysis of controlled clinical trials

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