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Both prebiotics, in the form of oligofructose-enriched inulin supplement, and oligofructose act as both pre- and probiotics to decrease the severity of celiac disease, with the former combatting dysbiosis and the latter down-regulating duodenal macrophage activity [74]

doi:10.1111/opo.12406

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Reactive oxygen and nitrogen species at physiological concentrations are regulators of numerous cellular functions: cellular signaling pathway, control of cell survival, regulation of vascular tone, signal transduction by cell membrane receptors, membrane renewal, synthesis and release of hormones, increase of inflammatory cytokine transcription regulation of the immune system (Robberecht, 2000