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This article serves to review the normal intestinal barrier, measurement of barrier permeability, pathogenesis and main causes of altered permeability, and highlight potential alternative therapies of leaky gut in horses while relating what has been studied in other species

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Current areas of scientific investigation include cellular integrity and cytoprotective signaling studies, endothelial and vascular pathway research, inflammatory signaling pathway analysis, peptide stability and degradation studies, cellular stress response research, and biochemical signaling network evaluation