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Start your intake Clinical Trial Data: What 3 Months Actually Shows Semaglutide trials (STEP program) demonstrated average 1013% weight loss at 3 months in patients with obesity, with approximately 70% losing at least 5% body weight

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However, based on preclinical data and early human trial findings, glucagon receptor co-activation in the context of concurrent GLP-1R and GIPR agonism is hypothesised to: Increase energy expenditure, potentially by promoting thermogenesis Enhance hepatic fat oxidation, which may reduce liver fat content Contribute to appetite suppression through central nervous system pathways These GCGR-mediated mechanisms are largely derived from preclinical and indirect human data and require confirmation in larger trials

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