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Di Rocco F, Roujeau T, Pujet S, Peyre M, Zerah M

PMID: 19386527 | doi:10.1016/j.ghir.2009.03.001 Falutz J et al

The number of human genes stimulated or suppressed by GHK, is greater than 4000, with a change greater than or equal to 50% is 31.2%

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A key challenge in studying native GLP-1 is its extremely short in vivo half-life of approximately 12 minutes, owing to rapid inactivation by dipeptidyl peptidase-4 (DPP-4), which cleaves the N-terminal His-Ala dipeptide from GLP-1 to produce the inactive metabolite GLP-1(936)amide