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This increase was associated with a 1.5-fold increase in portal plasma GLP-1 upon gastric glucose stimulation in diet-induced obese VSG rats compared to diet-induced obese sham controls, suggesting that antral GLP-1 producing cells contribute significantly to portal GLP-1 (Ribeiro-Parenti et al., 2021)

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This is a fascinating compound for researchers, a novel tri-agonist that targets glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors