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slow the administration Theoretical concerns Tumour promotion: animal studies at very high doses (far above clinical use) showed no pro-tumorigenic effects

Daijo K, Kawaoka T, Nakahara T, Nagaoki Y, Tsuge M, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Hara K, Tajima G, Kobayashi M, Chayama K

Weight loss during this period is often modest, perhaps 1 to 3 pounds, because the dose is below the threshold where all three receptors are fully engaged

Hair follicle support : Promotes scalp microcirculation and follicle health, supporting thicker, healthier hair growth cycles

Therefore, DEX-mediated increase in uric acid excretion is mainly due to the downregulation effect of URAT1 (Li et al., 2019)