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A series of placebo-controlled, randomized, double-blind clinical trials investigating intravenous or intranasal administration of GSH showed improvements in motor symptoms, but these improvements lacked statistical significance compared to placebo (203205)

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Finally, proactive engagement with regulatory agencies and education of clinicians will be crucial for the smooth incorporation of validated biomarkers into risk stratification models and for guiding future ferroptosis-targeted therapies in cardiovascular disease

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