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Whereas, further rise in the ROS level is accompanied with down regulation of cellular antioxidant defense systems in tumor malignancy through various molecular targets including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and nuclear respiratory factor 2 (Nrf2) [6, 7]

To address these challenges and promote appropriate medication use, many insurers implement utilization management tools like prior authorization and step therapy

However, this study has some limitations

Lack of signaling pathways that can modulate ACD occurrence suggests that ACD cannot be targeted pharmaceutically [4]

Ethell IM, Ethell DW