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Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins

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reported improvements in clinical attachment level (CAL), probing depth (PD), gingival recession (REC) , and probing bone levels, after using hyaluronic acid hydrogel scaffolds enriched with fibroblast growth factor type 2 (fhFGF-2) in the surgical treatment of periodontal intrabony defects

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