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Level 2 evidence corresponds to cohort studies or systematic reviews of cohort studies

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It adds that a qualified provider should assess personal and family history of medullary thyroid carcinoma along with pancreatitis risk as part of the same review

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Notably absent from that list is lithium, which is only approved in bipolar disorder despite ranking first line for antidepressant augmentation in five treatment guidelines (Taylor RW et al, Int J Neuropsychopharmacol 2020;23(9):587625)