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A.BrownK.RamayH.et al (2020)

Sermorelin and CJC-1295 mimic the body's natural GHRH signal Ipamorelin mimics ghrelin receptor activation to promote GH release IGF-1 LR3 bypasses Growth Hormone production altogether and acts directly on IGF-1 receptors in target tissues Understanding these mechanisms helps explain why each compound produces different physiologic effects and why they are often used in different clinical and research settings

Although the mechanisms by which these reagents modulate GPx1 expression are not clear, it has been shown that GPx1 can be upregulated by activation of the peroxisome proliferator-activated receptor--coactivator-1a (PGC1) pathway, possibly via the subsequent activation of Nrf2 [161]

Ultimately, 9 studies met the inclusion criteria and were included in the final review

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