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Finally, stress-translation coupling remains debatedsome earlier models posited widespread 5-UTR m 6 A-driven cap-independent initiation during the integrated stress response, whereas more recent ribosome-centric work argues for context-limited effectsso careful reconciliation with disease settings is warranted ( 2.4 Interaction between RNA modifications and tumor microenvironment 2.4.1 The impact of RNA modifications on immune cell infiltration in the tumor microenvironment Building on Sections 2.3.22.3.3, a convergent body of in vivo work now shows that RNA modificationsmost clearly m 6 A decoded by YTH-family and IGF2BP readersreconfigure which immune populations can access, or are excluded from tumors

10.1038/nm.4464 177 SeltzerM

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Recovery and resilience: NAD+ plays a role in the bodys natural repair mechanisms