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Research shows that both moderate-intensity continuous training (MICT, 50%70% VO 2 max) and high-intensity interval training (HIIT, 85%95% VO 2 max) can effectively activate the Nrf2 pathway, with HIIT being 30%40% more effective in upregulating antioxidant enzymes than MICT (Martinez-Canton et al., 2024)

Nature 556:113117

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The combined effect of these changes likely explains the 50% decrease in total hepatic TG content in CON-fed KO mice

Given the central importance of iron and membrane polyunsaturated fatty acyls, mutations that disrupt either iron uptake or the incorporation of lipids into cellular membranes can both act as potent suppressors of ferroptosis