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In summary, from modulating microglial polarization and neutralizing pro-inflammatory cytokines, to targeting immune checkpoints and astrocyte-derived inhibitory pathways, immunomodulatory strategies offer multifaceted approaches to disrupt the ferroptosisinflammation interplay

Melanin modulation: The glutathione reroutes melanin production to pheomelanin (lighter pigment) instead of eumelanin

Abuse is the intentional, non-therapeutic use of a drug, even once, for its desirable psychological or physiological effects