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6.2 BBB protection and repair 6.2.1 Tight junction stabilizers Tight junctions are a crucial component of the BBB, and their dysfunction leads to increased vascular permeability

Indeed, excess hemin and iron contents and hypoxic stress in the tissues including spleen and liver exacerbated SCD clinical severity 59,60,61,62

Berberine Berberine is another plant compound with medicinal benefits, often used for metabolic and gut support

Chlorogenic acid is a P450 enzyme inhibitor, which can decrease the expression of CYP2E1 and CYP1A2 (Pang et al., 2015)

Therefore,this amino acid that has many properties as long as we take the recommended dose