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Exposures and Outcomes Exposures to the index medication were identified from outpatient dispensing records, where medication classes were defined by National Drug Codes based on Anatomical Therapeutic Chemical (ATC)-defined medication classes (ESM Table S2)

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Restoration of the NAD + levels by niacin, a NAD + precursor and B3 vitamin, provided health benefits, slowly reversing physical performance of some adult patients 15 .To find patients who have NAD + deficiency and could benefit from B3 treatment, we needed to set up validated technology and assess their values in the normal population

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