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Future research aims to refine receptor targeting to minimize side effects while maintaining therapeutic benefits

Hormonal life stages such as perimenopause and menopause can affect weight management

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In support of this, exploratory analyses revealed that the semaglutide group exhibited markers of more advanced metabolic disease relative to the off-semaglutide group, including a greater number of diabetes medication classes, a higher prevalence of diabetes-relevant cardiometabolic comorbidities, and a greater cardiovascular medication burden

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