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Often a loading dose is given in patients with severe metabolic crisis, followed by an equivalent dose over the following 24 hours

3csh: LJ Parker, S Ciccone, LC Italiano, A Primavera, AJ Oakley, CJ Morton, NC Hancock, M Lo Bello & MW Parker (2008) The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterization of allelic variants

It helps to release insulin and lowers the amount of glucose produced by the liver when glucose rises at mealtime

That can sound strange at first